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human disease network
Human disease network is a network of human disorders and diseases with reference to their genetic origins or other features. More specifically, it is the map of human diseases associations referring mostly to disease genes. For example, in a human disease network, two diseases are linked if they share at least one associated gene. A typical human disease network usually derives from bipartite networks which consist of both diseases and genes information. Besides, some human disease networks also use other features like symptoms, proteins, etc. to associate diseases.
==History==
In 2007, Goh et al. constructed a disease-gene bipartite graph using information from OMIM database and termed human disease network.〔Goh, Kwang-Il, et al. "The human disease network." Proceedings of the National Academy of Sciences 104.21 (2007): 8685-8690.〕 In 2009, Barrenas et al. derived complex disease-gene network using GWAs (Genome Wide Association studies).〔Barrenas, Fredrik, et al. "Network properties of complex human disease genes identified through genome-wide association studies." PloS one 4.11 (2009): e8090.〕 In the same year, Hidalgo et al. published a novel way of building human phenotypic disease networks in which diseases were connected according to their calculated distance.〔Hidalgo, César A., et al. "A dynamic network approach for the study of human phenotypes." PLoS computational biology 5.4 (2009): e1000353.〕 In 2011, Cusick et al. summarized studies on genotype-phenotype associations in cellular context.〔Vidal, Marc, Michael E. Cusick, and Albert-Laszlo Barabasi. "Interactome networks and human disease." Cell 144.6 (2011): 986-998.〕 In 2014, Zhou, et al. built a symptom-based human disease network by mining biomedical literature database.〔Zhou, XueZhong, et al. "Human symptoms–disease network." Nature communications 5 (2014).〕
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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